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Article

Site-specific structural constraints on protein sequence evolutionary divergence: local packing density versus solvent exposure.

Molecular biology and evolution - 1 Jan 2014

Yeh So-Wei, Liu Jen-Wei, Yu Sung-Huan, Shih Chien-Hua, Hwang Jenn-Kang, Echave Julian

Abstract excerpt

Protein sequences evolve under selection pressures imposed by functional and biophysical requirements, resulting in site-dependent rates of amino acid substitution. Relative solvent accessibility (RSA) and local packing density (LPD) have emerged as the best candidates to quantify structural constraint. Recent research assumes that RSA is the main determinant of sequence divergence. However, it is not yet clear...

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Identifiers

PMID: 24109601
DOI: 10.1093/molbev/mst178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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