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Article

Protein conformational diversity modulates sequence divergence.

Molecular biology and evolution - 1 Jan 2013

Juritz Ezequiel, Palopoli Nicolas, Fornasari Maria Silvina, Fernandez-Alberti Sebastian, Parisi Gustavo

Abstract excerpt

It is well established that the conservation of protein structure during evolution constrains sequence divergence. The conservation of certain physicochemical environments to preserve protein folds and then the biological function originates a site-specific structurally constrained substitution pattern. However, protein native structure is not unique. It is known that the native state is better described by an...

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PMID: 22396525
DOI: 10.1093/molbev/mss080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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