Article
Tertiary structural constraints on protein evolutionary diversity: templates, key residues and structure prediction.
Proceedings. Biological sciences - 22 Aug 1990
Overington J, Johnson M S, Sali A, Blundell T L
Abstract excerpt
The pattern of residue substitution in divergently evolving families of globular proteins is highly variable. At each position in a fold there are constraints on the identities of amino acids from both the three-dimensional structure and the function of the protein. To characterize and quantify the structural constraints, we have made a comparative analysis of families of homologous globular proteins. Residues...
Topics
- Amino Acid Sequence
- Animals
- Biological Evolution
- Genetic Variation
- Humans
- Molecular Sequence Data
- Probability
- Protein Conformation
- Proteins