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Article

Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.

Genetics - 1 Apr 2018

Jiang Qian, Teufel Ashley I, Jackson Eleisha L, Wilke Claus O

Abstract excerpt

Biological evolution generates a surprising amount of site-specific variability in protein sequences. Yet, attempts at modeling this process have been only moderately successful, and current models based on protein structural metrics explain, at best, 60% of the observed variation. Surprisingly, simple measures of protein structure, such as solvent accessibility, are often better predictors of site-specific...

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Identifiers

PMID: 29382650
DOI: 10.1534/genetics.118.300699
PMCID: PMC5887137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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