Article
Beyond Thermodynamic Constraints: Evolutionary Sampling Generates Realistic Protein Sequence Variation.
Genetics - 1 Apr 2018
Jiang Qian, Teufel Ashley I, Jackson Eleisha L, Wilke Claus O
Abstract excerpt
Biological evolution generates a surprising amount of site-specific variability in protein sequences. Yet, attempts at modeling this process have been only moderately successful, and current models based on protein structural metrics explain, at best, 60% of the observed variation. Surprisingly, simple measures of protein structure, such as solvent accessibility, are often better predictors of site-specific...
Topics
- Algorithms
- Amino Acid Substitution
- Computer Simulation
- Evolution, Molecular
- Genetic Variation
- Protein Conformation
- Proteins
- Sequence Alignment
- Structure-Activity Relationship
- Thermodynamics