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Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus

28 Sept 2005

Abstract excerpt

Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. Cubicin (daptomycin-for-injection) was approved in 2003 by the FDA to treat skin and skin structure infections caused by Gram-positive pathogens. Daptomycin is particularly significant in that it represents the first new natural product antibacterial structural class approved for clinical use in three decades. The daptomycin gene...

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PMID: 16193281
DOI: 10.1007/s10295-005-0030-y

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