Article
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.
Science (New York, N.Y.) - 16 Sept 2011
Scheid Johannes F, Mouquet Hugo, Ueberheide Beatrix, Diskin Ron, Klein Florian, Oliveira Thiago Y K, Pietzsch John, Fenyo David, Abadir Alexander, Velinzon Klara, Hurley Arlene, Myung Sunnie, Boulad Farid, Poignard Pascal, Burton Dennis R, Pereyra Florencia, Ho David D, Walker Bruce D, Seaman Michael S, Bjorkman Pamela J, Chait Brian T, Nussenzweig Michel C
Abstract excerpt
Passive transfer of broadly neutralizing HIV antibodies can prevent infection, which suggests that vaccines that elicit such antibodies would be protective. Thus far, however, few broadly neutralizing HIV antibodies that occur naturally have been characterized. To determine whether these antibodies are part of a larger group of related molecules, we cloned 576 new HIV antibodies from four unrelated individuals....
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