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[Functional Responses to the Chronic Activation of 5-HT1A Receptors in Mice with Genetic Predisposition to Catalepsy].

Molekuliarnaia biologiia - 1 Jan 2000

Tsybko A S, Ilchibaeva T V, Bazovkina D V, Naumenko V S

Abstract excerpt

The effects of chronic 5-HT1A receptor activation on the behavior, functional activity of 5-HT1A receptors, and expression of key genes of the brain 5-HT system were studied in mice of the catalepsy-prone CBA strain and the catalepsy-resistant C57BL/6 strain. Chronic treatment with 8-Hydroxy-2-(di-n-propyl-amino)tetralin (8-OH-DPAT) (1.0 mg/kg i.p., 14 days) led to a significant decrease in the hypothermic...

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Share to Genetic Predisposition to Disease
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Share to Receptor, Serotonin, 5-HT1A

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PMID: 29695693
DOI: 10.7868/S0026898418020088

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