Article
Effect of brain-derived neurotrophic factor on behavior and key members of the brain serotonin system in genetically predisposed to behavioral disorders mouse strains.
Neuroscience - 12 Jul 2012
Naumenko V S, Kondaurova E M, Bazovkina D V, Tsybko A S, Tikhonova M A, Kulikov A V, Popova N K
Abstract excerpt
The effect of brain-derived neurotrophic factor (BDNF) on depressive-like behavior and serotonin (5-HT) system in the brain of antidepressant sensitive cataleptics (ASC)/Icg mouse strain, characterized by depressive-like behavior, in comparison with the parental nondepressive CBA/Lac mouse strain was examined. Significant decrease of catalepsy and tail suspension test (TST) immobility was shown 17days after acute...
Topics
- Animals
- Brain
- Brain-Derived Neurotrophic Factor
- Depressive Disorder
- Genetic Predisposition to Disease
- Injections, Intraventricular
- Male
- Mice
- Mice, Inbred CBA
- Neurogenesis
- Receptor, Serotonin, 5-HT1A
- Receptor, Serotonin, 5-HT2A