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Article

Multiple mutations within individual oncogenes.

Cancer science - 1 Feb 2021

Saito Yuki, Koya Junji, Kataoka Keisuke

Abstract excerpt

Recent studies of the cancer genome have identified numerous patients harboring multiple mutations (MM) within individual oncogenes. These MM (de novo MM) in cis synergistically activate the mutated oncogene and promote tumorigenesis, indicating a positive epistatic interaction between mutations. The relatively frequent de novo MM suggest that intramolecular positive epistasis is widespread in oncogenes. Studies...

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Identifiers

PMID: 33073435
DOI: 10.1111/cas.14699
PMCID: PMC7894016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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