Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.

PLoS genetics - 1 Oct 2020

Lascarez-Lagunas Laura I, Herruzo Esther, Grishok Alla, San-Segundo Pedro A, Colaiácovo Mónica P

Abstract excerpt

Epigenetic modifiers are emerging as important regulators of the genome. However, how they regulate specific processes during meiosis is not well understood. Methylation of H3K79 by the histone methyltransferase Dot1 has been shown to be involved in the maintenance of genomic stability in various organisms. In S. cerevisiae, Dot1 modulates the meiotic checkpoint response triggered by synapsis and/or recombination...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Pairing

Share to Chromosomes

Share to Histone-Lysine N-Methyltransferase

Share to Meiosis

Share to Recombination, Genetic

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33104701
DOI: 10.1371/journal.pgen.1009171
PMCID: PMC7644094

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans.PMID 33104701Read ↗

Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.Semantic proximity Read ↗

Role for the silencing protein Dot1 in meiotic checkpoint control.Semantic proximity Read ↗

Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.Semantic proximity Read ↗

Dot1-dependent histone H3K79 methylation promotes the formation of meiotic double-strand breaks in the absence of histone H3K4 methylation in budding yeast.Semantic proximity Read ↗

Aberrant activation of chromosome asynapsis checkpoint triggers oocyte eliminationSemantic proximity Read ↗

HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis.Semantic proximity Read ↗

Nuclear localization of the meiosis-specific transcription factor Ndt80 is regulated by the pachytene checkpoint.Semantic proximity Read ↗

Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.Semantic proximity Read ↗

Fission yeast mutants affecting telomere clustering and meiosis-specific spindle pole body integrity.Semantic proximity Read ↗

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read ↗

Three distinct modes of Mec1/ATR and Tel1/ATM activation illustrate differential checkpoint targeting during budding yeast early meiosis.Semantic proximity Read ↗

Zebrafish lack a strong meiotic checkpoint response to defects in chromosome synapsisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.