G‐protein coupled receptor 56 promotes myoblast fusion through serum response factor‐ and nuclear factor of activated T‐cell‐mediated signalling but is not essential for muscle development in vivo

Abstract excerpt

Mammalian muscle cell differentiation is a complex process of multiple steps for which many of the factors involved have not yet been defined. In a screen to identify the regulators of myogenic cell fusion, we found that the gene for G-protein coupled receptor 56 (GPR56) was transiently up-regulated during the early fusion of human myoblasts. Human mutations in the gene for GPR56 cause the disease bilateral...

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