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Article

Association studies indicate that protein disulfide isomerase is a risk factor in amyotrophic lateral sclerosis.

Free radical biology & medicine - 1 May 2013

Kwok Chun Tak, Morris Alex G, Frampton Jenny, Smith Bradley, Shaw Christopher E, de Belleroche Jackie

Abstract excerpt

Protein disulfide isomerase (PDI) plays an important role in the endoplasmic reticulum (ER) by facilitating the exchange of disulfide bonds and, together with other ER stress proteins, is induced in amyotrophic lateral sclerosis (ALS). However, genetic polymorphisms in the P4HB gene, which encodes PDI, have not been thoroughly investigated in ALS cases. In this study, we determined whether single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23337974
DOI: 10.1016/j.freeradbiomed.2013.01.001

Genes

SOD1

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