Article
Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.
Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013
Adler Jacob J, Johnson Derrick E, Heller Brigitte L, Bringman Lauren R, Ranahan William P, Conwell Michael D, Sun Yang, Hudmon Andy, Wells Clark D
Abstract excerpt
Large tumor suppressor (LATS)1/2 protein kinases transmit Hippo signaling in response to intercellular contacts and serum levels to limit cell growth via the inhibition of Yes-associated protein (YAP). Here low serum and high LATS1 activity are found to enhance the levels of the 130-kDa isoform of angiomotin (Amot130) through phosphorylation by LATS1/2 at serine 175, which then forms a binding site for 14-3-3....
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