Article
WIP Drives Tumor Progression through YAP/TAZ-Dependent Autonomous Cell Growth.
Cell reports - 15 Nov 2016
Gargini Ricardo, Escoll Maribel, García Esther, García-Escudero Ramón, Wandosell Francisco, Antón Inés María
Abstract excerpt
In cancer, the deregulation of growth signaling pathways drives changes in the cell's architecture and its environment that allow autonomous growth of tumors. These cells then acquire a tumor-initiating "stemness" phenotype responsible for disease advancement to more aggressive stages. Here, we show that high levels of the actin cytoskeleton-associated protein WIP (WASP-interacting protein) correlates with tumor...
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