Article
Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis.
Cell communication and signaling : CCS - 23 Oct 2020
Marquard Simone, Thomann Stefan, Weiler Sofia M E, Bissinger Michaela, Lutz Teresa, Sticht Carsten, Tóth Marcell, de la Torre Carolina, Gretz Norbert, Straub Beate K, Marquardt Jens, Schirmacher Peter, Breuhahn Kai
Abstract excerpt
BACKGROUND: Overexpression and nuclear enrichment of the oncogene yes-associated protein (YAP) cause tumor initiation and support tumor progression in human hepatocellular carcinoma (HCC) via cell autonomous mechanisms. However, how YAP expression in tumor cells affects intercellular communication within the tumor microenvironment is not well understood. METHODS: To investigate how tumor cell-derived YAP is...
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