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Article

Pore waters regulate ion permeation in a calcium release-activated calcium channel.

Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013

Dong Hao, Fiorin Giacomo, Carnevale Vincenzo, Treptow Werner, Klein Michael L

Abstract excerpt

The recent crystal structure of Orai, the pore unit of a calcium release-activated calcium (CRAC) channel, is used as the starting point for molecular dynamics and free-energy calculations designed to probe this channel's conduction properties. In free molecular dynamics simulations, cations localize preferentially at the extracellular channel entrance near the ring of Glu residues identified in the crystal...

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Identifiers

PMID: 24101457
DOI: 10.1073/pnas.1316969110
PMCID: PMC3808583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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