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Article

Orai1 pore residues control CRAC channel inactivation independently of calmodulin.

The Journal of general physiology - 1 Feb 2016

Mullins Franklin M, Yen Michelle, Lewis Richard S

Abstract excerpt

Ca(2+) entry through CRAC channels causes fast Ca(2+)-dependent inactivation (CDI). Previous mutagenesis studies have implicated Orai1 residues W76 and Y80 in CDI through their role in binding calmodulin (CaM), in agreement with the crystal structure of Ca(2+)-CaM bound to an Orai1 N-terminal peptide. However, a subsequent Drosophila melanogaster Orai crystal structure raises concerns about this model, as the...

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Identifiers

PMID: 26809793
DOI: 10.1085/jgp.201511437
PMCID: PMC4727942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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