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Article

Counterion-assisted cation transport in a biological calcium channel.

The journal of physical chemistry. B - 14 Aug 2014

Dong Hao, Klein Michael L, Fiorin Giacomo

Abstract excerpt

How ions pass through the lumen of an ion channel is a key question underlying cellular communication. The effects of water and pore-lining residues (channel design) have been extensively explored. However, the role of counterions is less well understood. The pore subunit of the calcium release-activated calcium channel, Orai, provides a useful model to explore the effect of anions on the permeation of cations....

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Identifiers

PMID: 25068680
DOI: 10.1021/jp5059897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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