Pathogen-sensing, regulatory T cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated T-cell responses.

Abstract excerpt

The concept that induction of T-cell-dependent immune responses requires both T-cell recognition of an epitope and recognition by the innate immune system of pathogen-associated molecular patterns needs to be extended to include the contribution of regulatory T cells and of responsiveness-tuning. Here we develop the hypothesis that both pathogen sensing and regulatory T cells act on antigen-presenting dendritic...

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