Article
The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells.
Immunity, inflammation and disease - 1 Feb 2022
Herppich Susanne, Beckstette Michael, Huehn Jochen
Abstract excerpt
BACKGROUND & AIMS: Thymic conventional dendritic cells (t-DCs) are crucial for the development of T cells. A substantial fraction of t-DCs originates extrathymically and migrates to the thymus. Here, these cells contribute to key processes of central tolerance like the clonal deletion of self-reactive thymocytes and the generation of regulatory T (Treg) cells. So far, it is only incompletely understood which...
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