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Article

Identifying the Cells Breaching Self-Tolerance in Autoimmunity

26 Apr 2010

Abstract excerpt

Activation of auto-reactive T cells by activated dendritic cells (DCs) presenting self-Ag is widely assumed to be the precipitating event in the development of autoimmune disease. However, despite such widely held preconceptions, supporting data are scarce and subjective, particularly in experimental arthropathy. We have adapted a novel murine model of breach of self-tolerance allowing evaluation of the...

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PMID: 20421640
DOI: 10.4049/jimmunol.0903951

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