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Article

Transient microstructural brain anomalies and epileptiform discharges in mice defective for epilepsy and language-related NMDA receptor subunit gene Grin2a.

Epilepsia - 1 Oct 2018

Salmi Manal, Bolbos Radu, Bauer Sylvian, Minlebaev Marat, Burnashev Nail, Szepetowski Pierre

Abstract excerpt

OBJECTIVE: The epilepsy-aphasia spectrum (EAS) is a heterogeneous group of age-dependent childhood disorders characterized by sleep-activated discharges associated with infrequent seizures and language, cognitive, and behavioral deficits. Defects in the GRIN2A gene, encoding a subunit of glutamate-gated N-methyl-d-aspartate (NMDA) receptors, represent the most important cause of EAS identified so far. Neocortical...

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PMID: 30146685
DOI: 10.1111/epi.14543

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