Article
Protein kinase C η is required for T cell activation and homeostatic proliferation.
Science signaling - 6 Dec 2011
Fu Guo, Hu Jianfang, Niederberger-Magnenat Nathalie, Rybakin Vasily, Casas Javier, Yachi Pia P, Feldstein Stephanie, Ma Bo, Hoerter John A H, Ampudia Jeanette, Rigaud Stephanie, Lambolez Florence, Gavin Amanda L, Sauer Karsten, Cheroutre Hilde, Gascoigne Nicholas R J
Abstract excerpt
Protein kinase C η (PKCη) is abundant in T cells and is recruited to the immunological synapse that is formed between a T cell and an antigen-presenting cell; however, its function in T cells is unknown. We showed that PKCη was required for the activation of mature CD8+ T cells through the T cell receptor. Compared with wild-type T cells, PKCη-/- T cells showed poor proliferation in response to antigen...
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