Article
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis.
The Journal of experimental medicine - 17 Oct 2005
Chang Xing, Gao Jian Xin, Jiang Qi, Wen Jing, Seifers Nick, Su Lishan, Godfrey Virginia L, Zuo Tao, Zheng Pan, Liu Yang
Abstract excerpt
The Scurfy mutation of the FoxP3 gene (FoxP3(sf)) in the mouse and analogous mutations in human result in lethal autoimmunity. The mutation of FoxP3 in the hematopoietic cells impairs the development of regulatory T cells. In addition, development of the Scurfy disease also may require mutation of the gene in nonhematopoietic cells. The T cell-extrinsic function of FoxP3 has not been characterized. Here we show...
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