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Article

Inhibition of telomerase recruitment and cancer cell death.

The Journal of biological chemistry - 15 Nov 2013

Nakashima Mai, Nandakumar Jayakrishnan, Sullivan Kelly D, Espinosa Joaquín M, Cech Thomas R

Abstract excerpt

Continued proliferation of human cells requires maintenance of telomere length, usually accomplished by telomerase. Telomerase is recruited to chromosome ends by interaction with a patch of amino acids (the TEL patch, for TPP1 glutamate (E) and leucine (L)-rich patch) on the surface of telomere protein TPP1. In previous studies, interruption of this interaction by mutation prevented telomere extension in HeLa...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24097987
DOI: 10.1074/jbc.M113.518175
PMCID: PMC3829164

Genes

TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of telomerase recruitment and cancer cell death.PMID 24097987Read ↗

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