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Article

Telomere loss in cells treated with cisplatin

14 Apr 1998

Abstract excerpt

Telomeres play an important role in the immortalization of proliferating cells. The long tandem repeats of 5'-TTAGGG-3' sequences in human telomeres are potential targets for the anticancer drug cisplatin, which forms mainly intrastrand d(GpG) and d(ApG) cross-links on DNA. The present study reveals that telomeres in cisplatin-treated HeLa cells are markedly shortened and degraded. A dose that killed 61% of the...

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Share to Advanced biosensing and bioanalysis techniques
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Identifiers

PMID: 9539717
DOI: 10.1073/pnas.95.8.4219

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