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Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532

27 Oct 2004

Abstract excerpt

Telomerase represents an attractive target for a mechanism-based therapeutic approach because its activation has been associated with unlimited proliferation in most cancer cells. Recently, a nonnucleosidic small molecule inhibitor, BIBR1532 (2-[(E)-3-naphtalen-2-yl-but-2-enoylamino]-benzoic acid), has been identified that is highly selective for inhibition of telomerase, resulting in delayed growth arrest of...

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PMID: 15507522
DOI: 10.1182/blood-2003-12-4322

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Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532PMID 15507522Read ↗

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