Article
Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A.
Proceedings of the National Academy of Sciences of the United States of America - 29 Jul 2014
Gupta Romi, Dong Yuying, Solomon Peter D, Wettersten Hiromi I, Cheng Christopher J, Min Jin-Na, Henson Jeremy, Dogra Shaillay Kumar, Hwang Sung H, Hammock Bruce D, Zhu Lihua J, Reddel Roger R, Saltzman W Mark, Weiss Robert H, Chang Sandy, Green Michael R, Wajapeyee Narendra
Abstract excerpt
Tumor suppressor p53 plays an important role in mediating growth inhibition upon telomere dysfunction. Here, we show that loss of the p53 target gene cyclin-dependent kinase inhibitor 1A (CDKN1A, also known as p21(WAF1/CIP1)) increases apoptosis induction following telomerase inhibition in a variety of cancer cell lines and mouse xenografts. This effect is highly specific to p21, as loss of other checkpoint...
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