Article
Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo.
Nature cell biology - 1 May 2022
Yang Hui, Bai Dandan, Li Yanhe, Yu Zhaowei, Wang Chenfei, Sheng Yifan, Liu Wenqiang, Gao Shaorong, Zhang Yong
Abstract excerpt
Parental DNA methylation and histone modifications undergo distinct global reprogramming in mammalian pre-implantation embryos, but the landscape of epigenetic crosstalk and its effects on embryogenesis are largely unknown. Here we comprehensively analyse the association between DNA methylation and H3K9me3 reprogramming in mouse pre-implantation embryos and reveal that CpG-rich genomic loci with high H3K9me3...
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