Article
Common variants in cardiac ion channel genes are associated with sudden cardiac death.
Circulation. Arrhythmia and electrophysiology - 1 Jun 2010
Albert Christine M, MacRae Calum A, Chasman Daniel I, VanDenburgh Martin, Buring Julie E, Manson JoAnn E, Cook Nancy R, Newton-Cheh Christopher
Abstract excerpt
BACKGROUND: Rare variants in cardiac ion channel genes are associated with sudden cardiac death in rare primary arrhythmic syndromes; however, it is unknown whether common variation in these same genes may contribute to sudden cardiac death risk at the population level. METHODS AND RESULTS: We examined the association between 147 single nucleotide polymorphisms (SNPs) (137 tag, 5 noncoding SNPs associated with QT...
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