Article
Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria.
Molecular and cellular neurosciences - 1 Dec 2005
Millar J Kirsty, James Rachel, Christie Sheila, Porteous David J
Abstract excerpt
Several independent studies have identified Disrupted In Schizophrenia 1 (DISC1) as a potential susceptibility factor in the pathogenesis of schizophrenia and severe recurrent major depression. To identify potential mechanisms by which DISC1 may influence development of psychiatric illness, we investigated the cellular consequences of recombinant DISC1 expression in COS-7 cells. We show that the N-terminal head...
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