Article
DISC1 Regulates Mitochondrial Trafficking in a Miro1-GTP-Dependent Manner
19 Jun 2020
Abstract excerpt
The disrupted in schizophrenia 1 (DISC1) protein is implicated in major mental illnesses including schizophrenia and bipolar disorder. A key feature of psychiatric disease is aberrant synaptic communication. Correct synaptic transmission is dependent on spatiotemporally regulated energy provision and calcium buffering. This can be achieved by precise distribution of mitochondria throughout the elaborate...
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