Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis.

Abstract excerpt

There is a growing body of evidence that components of the circadian clock are involved in modulation of numerous signaling pathways, and that clock deregulation due to environmental or genetic factors contributes to the development of various pathologies, including cancer. Previous work performed in tissue culture and in in vivo mouse models defined mammalian PERIOD proteins as tumor suppressors, although some...

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