Tumor suppression by the mammalian Period genes.

doi:10.1007/s10552-005-9003-8

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Article

Tumor suppression by the mammalian Period genes.

Cancer causes & control : CCC - 1 May 2006

Lee Cheng Chi

Abstract excerpt

The Period (Per) genes are key circadian rhythm regulators in mammals. Expression of the mouse Per (mPer) genes have diurnal pattern in the suprachiamstic nuclei and in peripheral tissues. Genetic ablation mPER1 and mPER2 function results in a complete loss of circadian rhythm control based on wheel running activity in mice. In addition, these animals also display apparent premature aging and significant increase...

Topics

Activity Cycles
Animals
Biological Clocks
Cell Cycle
Cell Proliferation
Circadian Rhythm
Eye Proteins
Humans
Mice
Mice, Mutant Strains
Neoplasms
Nuclear Proteins
Period Circadian Proteins
Phenotype
Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 16596306
DOI: 10.1007/s10552-005-9003-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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