Article
Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis.
Cell cycle (Georgetown, Tex.) - 1 May 2008
Antoch Marina P, Gorbacheva Victoria Y, Vykhovanets Olena, Toshkov Illia A, Kondratov Roman V, Kondratova Anna A, Lee Choogon, Nikitin Alexander Yu
Abstract excerpt
The mammalian circadian system has been implicated in the regulation of various biological processes including those involved in genotoxic stress responses and tumor suppression. Here we report that mice with the functional deficiency in circadian transcription factor CLOCK (Clock/Clock mutant mice) do not display predisposition to tumor formation both during their normal lifespan or when challenged by gamma-...
Topics
- Aging
- Aging, Premature
- Animals
- Apoptosis
- CLOCK Proteins
- Cell Proliferation
- Cell Transformation, Neoplastic
- Chronobiology Disorders
- Circadian Rhythm
- Down-Regulation