Article
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo.
Cell - 4 Oct 2002
Fu Loning, Pelicano Helene, Liu Jinsong, Huang Peng, Lee Cheng
Abstract excerpt
The Period2 gene plays a key role in controlling circadian rhythm in mice. We report here that mice deficient in the mPer2 gene are cancer prone. After gamma radiation, these mice show a marked increase in tumor development and reduced apoptosis in thymocytes. The core circadian genes are induced by gamma radiation in wild-type mice but not in mPer2 mutant mice. Temporal expression of genes involved in cell cycle...
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