Article
Clock genes and cancer.
Integrative cancer therapies - 1 Dec 2009
Wood Patricia A, Yang Xiaoming, Hrushesky William J M
Abstract excerpt
Period genes ( Per2, Per1) are essential circadian clock genes. They also function as negative growth regulators. Per2 mutant mice show de novo and radiation-induced epithelial hyperplasia, tumors, and an abnormal DNA damage response. Human tumors show Period gene mutations or decreased expression. Other murine clock gene mutations are not associated with a tumor prone phenotype. Shift work and nocturnal light...
Topics
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Circadian Rhythm
- Colonic Neoplasms
- Colonic Polyps
- Gene Expression
- Gene Expression Regulation, Neoplastic
- Mice
- Mice, Mutant Strains
- Mutation
- Neoplasms