Article
Clock genes and cancer.
Integrative cancer therapies - 1 Dec 2009
Wood Patricia A, Yang Xiaoming, Hrushesky William J M
Abstract excerpt
Period genes ( Per2, Per1) are essential circadian clock genes. They also function as negative growth regulators. Per2 mutant mice show de novo and radiation-induced epithelial hyperplasia, tumors, and an abnormal DNA damage response. Human tumors show Period gene mutations or decreased expression. Other murine clock gene mutations are not associated with a tumor prone phenotype. Shift work and nocturnal light...
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