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Article

p16INK4a protects against dysfunctional telomere–induced ATR-dependent DNA damage responses

15 Sept 2013

Abstract excerpt

Dysfunctional telomeres limit cellular proliferative capacity by activating the p53-p21- and p16(INK4a)-Rb-dependent DNA damage responses (DDRs). The p16(INK4a) tumor suppressor accumulates in aging tissues, is a biomarker for cellular senescence, and limits stem cell function in vivo. While the activation of a p53-dependent DDR by dysfunctional telomeres has been well documented in human cells and mouse models,...

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PMID: 24091330
DOI: 10.1172/jci69574

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