Article
Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita.
Molecular and cellular biology - 1 Jan 2009
He Hua, Wang Yang, Guo Xiaolan, Ramchandani Sonal, Ma Jin, Shen Mei-Feng, Garcia Dennis A, Deng Yibin, Multani Asha S, You Mingjian James, Chang Sandy
Abstract excerpt
The Protection of telomeres 1 (POT1) protein is a single-stranded telomere binding protein that is essential for proper maintenance of telomere length. Disruption of POT1 function leads to chromosome instability and loss of cellular viability. Here, we show that targeted deletion of the mouse Pot1b gene results in increased apoptosis in highly proliferative tissues. In the setting of telomerase...
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