A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency.

doi:10.1182/blood-2013-06-508267

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency.

Blood - 28 Nov 2013

Neven Bénédicte, Mamessier Emilie, Bruneau Julie, Kaltenbach Sophie, Kotlarz Daniel, Suarez Felipe, Masliah-Planchon Julien, Billot Katy, Canioni Danielle, Frange Pierre, Radford-Weiss Isabelle, Asnafi Vahid, Murugan Dhaarini, Bole Christine, Nitschke Patrick, Goulet Olivier, Casanova Jean-Laurent, Blanche Stéphane, Picard Capucine, Hermine Olivier, Rieux-Laucat Frederic, Brousse Nicole, Davi Frederic, Baud Véronique, Klein Christoph, Nadel Bertrand, Ruemmele Frank, Fischer Alain

Abstract excerpt

Monogenic interleukin-10 (IL-10) and IL-10 receptor (IL-10R) deficiencies cause very early onset severe inflammatory bowel disease. Here, we report that 5 patients with an IL-10R1 (n = 1) or IL-10R2 (n = 4) deficiency developed B-cell non-Hodgkin lymphoma between the ages of 5 and 6 years (which was recurrent in 1 patient). These lymphomas had some of the characteristics of diffuse large B-cell lymphomas and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Germinal Center

Share to Inflammatory Bowel Diseases

Share to Interleukin-10

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to NF-kappa B

Source

Open in PubMed

Identifiers

PMID: 24089328
DOI: 10.1182/blood-2013-06-508267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency.PMID 24089328Read ↗

The clinical, molecular, and therapeutic features of patients with IL10/IL10R deficiency: a systematic review.Semantic proximity Read ↗

Immune Dysregulation Resulting From Impaired Interleukin-10 And The Interleukin-10 Receptor Signaling: A Systematic Review of 284 Monogenic PatientsSemantic proximity Read ↗

A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside.Semantic proximity Read ↗

Phenotypic Characterization of Very Early-Onset Inflammatory Bowel Disease with Interleukin-10 Signaling Deficiency: Based on a Large Cohort Study.Semantic proximity Read ↗

Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group.Semantic proximity Read ↗

[Clinicopathological features of pediatric monogenic inflammatory bowel disease associated with both IL-10 and non-IL-10 pathways: a differential analysis].Semantic proximity Read ↗

IL-10 and IL-10 receptor defects in humans.Semantic proximity Read ↗

Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.Semantic proximity Read ↗

Very early onset inflammatory bowel disease: Investigation of the IL-10 signaling pathway in Iranian children.Semantic proximity Read ↗

Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease.Semantic proximity Read ↗

Thalidomide-mediated immunomodulation in a patient with IL-10RA deficiency-associated very early-onset inflammatory bowel disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.