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Thalidomide-mediated immunomodulation in a patient with IL-10RA deficiency-associated very early-onset inflammatory bowel disease.

Frontiers in immunology - 1 Jan 2026

Ren Aiyan, Zeng Qian, Zhang Bin, Chuan Xue, Wu Yalin, Wang Meiting, Ren Huan, Chen Yan, Huang Pei, Du Zuochen

Abstract excerpt

Introduction: Very early-onset inflammatory bowel disease (VEO-IBD) is frequently triggered by monogenic defects in the pathways responsible for immune system regulation, including mutations in the interleukin-10 receptor alpha (IL-10RA) gene. Patients often show severe and refractory clinical manifestations. Thalidomide has shown immunomodulatory effects in pediatric IBD; however, its immunological effects in...

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Immunomodulation
Infant
Inflammatory Bowel Diseases
Mutation
Thalidomide

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PMID: 42064076
DOI: 10.3389/fimmu.2026.1748151
PMCID: PMC13125077

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