Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analysis of selective constraints on high stability regions of mRNA reveals multiple compensatory mutations in Escherichia coli.

PloS one - 1 Jan 2013

Mao Yuanhui, Li Qian, Zhang Yinwen, Zhang Junjie, Wei Gehong, Tao Shiheng

Abstract excerpt

Message RNA (mRNA) carries a large number of local secondary structures, with structural stability to participate in the regulations of gene expression. A worthy question is how the local structural stability is maintained under the constraint that multiple selective pressures are imposed on mRNA local regions. Here, we performed the first genome-wide study of natural selection operating on high structural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Bacterial

Share to Genome-Wide Association Study

Share to Mutation

Share to Nucleic Acid Conformation

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 24086278
DOI: 10.1371/journal.pone.0073299
PMCID: PMC3785496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analysis of selective constraints on high stability regions of mRNA reveals multiple compensatory mutations in Escherichia coli.PMID 24086278Read ↗

A universal trend of reduced mRNA stability near the translation-initiation site in prokaryotes and eukaryotes.Semantic proximity Read ↗

Conservation of mRNA secondary structures may filter out mutations in Escherichia coli evolution.Semantic proximity Read ↗

The ancestral SgrS RNA discriminates horizontally acquired Salmonella mRNAs through a single G-U wobble pair.Semantic proximity Read ↗

Codon usage bias from tRNA's point of view: redundancy, specialization, and efficient decoding for translation optimization.Semantic proximity Read ↗

Coding-sequence determinants of gene expression in Escherichia coli.Semantic proximity Read ↗

Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly.Semantic proximity Read ↗

Strand-specific mutational bias influences codon usage of weakly expressed genes in Escherichia coli.Semantic proximity Read ↗

Predicting the effect of mutations to investigate recent events of selection across 60,472 Escherichia coli strains.Semantic proximity Read ↗

Large-scale in silico mutagenesis experiments reveal optimization of genetic code and codon usage for protein mutational robustness.Semantic proximity Read ↗

A slight mismatch between a gene's codon usage and the cellular tRNA supply is beneficial.Semantic proximity Read ↗

DNA sequences shaped by selection for stability.Semantic proximity Read ↗

Describing the structural robustness landscape of bacterial small RNAs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.