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Article

A universal trend of reduced mRNA stability near the translation-initiation site in prokaryotes and eukaryotes.

PLoS computational biology - 5 Feb 2010

Gu Wanjun, Zhou Tong, Wilke Claus O

Abstract excerpt

Recent studies have suggested that the thermodynamic stability of mRNA secondary structure near the start codon can regulate translation efficiency in Escherichia coli, and that translation is more efficient the less stable the secondary structure. We survey the complete genomes of 340 species for signals of reduced mRNA secondary structure near the start codon. Our analysis includes bacteria, archaea, fungi,...

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Identifiers

PMID: 20140241
DOI: 10.1371/journal.pcbi.1000664
PMCID: PMC2816680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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