Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013

Park Chungoo, Chen Xiaoshu, Yang Jian-Rong, Zhang Jianzhi

Abstract excerpt

The cause of the tremendous among-protein variation in the rate of sequence evolution is a central subject of molecular evolution. Expression level has been identified as a leading determinant of this variation among genes encoded in the same genome, but the underlying mechanisms are not fully understood. We here propose and demonstrate that a requirement for stronger folding of more abundant mRNAs results in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Fungal
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Conformation

Share to Proteins

Share to RNA, Fungal

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 23382244
DOI: 10.1073/pnas.1218066110
PMCID: PMC3581962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly.PMID 23382244Read ↗

Cotranslational protein folding reveals the selective use of synonymous codons along the coding sequence of a low expression gene.Semantic proximity Read ↗

Expression level, evolutionary rate, and the cost of expression.Semantic proximity Read ↗

Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presence.Semantic proximity Read ↗

Macroevolutionary divergence of gene expression driven by selection on protein abundance.Semantic proximity Read ↗

Selection on codon bias in yeast: a transcriptional hypothesis.Semantic proximity Read ↗

An integrated view of the correlations between genomic and phenomic variables.Semantic proximity Read ↗

Alternative mRNA processing sites decrease genetic variability while increasing functional diversity.Semantic proximity Read ↗

The Missing Expression Level-Evolutionary Rate Anticorrelation in Viruses Does Not Support Protein Function as a Main Constraint on Sequence Evolution.Semantic proximity Read ↗

Synonymous codon usage regulates translation initiationSemantic proximity Read ↗

Phylogenetic analysis reveals how selection and mutation shape the coevolution of mRNA and protein abundancesSemantic proximity Read ↗

The role of alternative splicing in adaptation and evolution.Semantic proximity Read ↗

Interplay between chaperones and protein disorder promotes the evolution of protein networks.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.