Article
Leucine-rich repeat and immunoglobulin domain-containing protein-1 (Lrig1) negative regulatory action toward ErbB receptor tyrosine kinases is opposed by leucine-rich repeat and immunoglobulin domain-containing protein 3 (Lrig3).
The Journal of biological chemistry - 26 Jul 2013
Rafidi Hanine, Mercado Francisco, Astudillo Michael, Fry William H D, Saldana Matthew, Carraway Kermit L, Sweeney Colleen
Abstract excerpt
Lrig1 is the founding member of the Lrig family of transmembrane leucine-rich repeat proteins, which also includes Lrig2 and Lrig3. Lrig1 is a negative regulator of oncogenic receptor tyrosine kinases, including ErbB and Met receptors, and promotes receptor degradation. Lrig1 has recently emerged...
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