Article
Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear.
Development (Cambridge, England) - 1 Dec 2008
Abraira Victoria E, Del Rio Tony, Tucker Andrew F, Slonimsky John, Keirnes Hannah L, Goodrich Lisa V
Abstract excerpt
The sense of balance depends on the intricate architecture of the inner ear, which contains three semicircular canals used to detect motion of the head in space. Changes in the shape of even one canal cause drastic behavioral deficits, highlighting the need to understand the cellular and molecular events that ensure perfect formation of this precise structure. During development, the canals are sculpted from...
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