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Article

Lrig2-Deficient Mice Are Protected against PDGFB-Induced Glioma

4 Sept 2013

Abstract excerpt

BACKGROUND: The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins constitute an integral membrane protein family that has three members: LRIG1, LRIG2, and LRIG3. LRIG1 negatively regulates growth factor signaling, but little is known regarding the functions of LRIG2 and LRIG3. In oligodendroglial brain tumors, high expression of LRIG2 correlates with poor patient survival. Lrig1 and Lrig3...

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PMID: 24023893
DOI: 10.1371/journal.pone.0073635

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