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Article

Modeling the effect of APC truncation on destruction complex function in colorectal cancer cells.

PLoS computational biology - 1 Jan 2013

Barua Dipak, Hlavacek William S

Abstract excerpt

In colorectal cancer cells, APC, a tumor suppressor protein, is commonly expressed in truncated form. Truncation of APC is believed to disrupt degradation of β-catenin, which is regulated by a multiprotein complex called the destruction complex. The destruction complex comprises APC, Axin, β-catenin, serine/threonine kinases, and other proteins. The kinases CK1α and GSK -3β, which are recruited by Axin, mediate...

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Identifiers

PMID: 24086117
DOI: 10.1371/journal.pcbi.1003217
PMCID: PMC3784502

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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