Article
Investigation of osteopontin levels and genomic variation of osteopontin and its receptors in Type 1 diabetes mellitus.
Journal of endocrinological investigation - 1 Dec 2013
Karamizadeh Z, Kamali Sarvestani E, Saki F, Karamifar H, Amirhakimi G H, Namavar Shooshtarian M H, Ashkani-Esfahani S
Abstract excerpt
BACKGROUND: Failure in self-tolerance towards β-cells in diabetes mellitus (DM) pathogenesis involves a series of complex events that are governed by environmental and genetic factors. Considering the importance of osteopontin (OPN) in T-helper-1 (Th1) cells development, the aim of this study was to evaluate the serum level and gene polymorphism of OPN in Iranian Type 1 diabetic (T1DM) children. METHODS: In this...
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