Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The osteopontin gene +1239A/C single nucleotide polymorphism is associated with type 1 diabetes mellitus in the Italian population.

International journal of immunopathology and pharmacology - 1 Jan 2000

Chiocchetti A, Orilieri E, Cappellano G, Barizzone N, D' Alfonso S, D' Annunzio G, Lorini R, Ravazzolo R, Cadario F, Martinetti M, Calcaterra V, Cerutti F, Bruno G, Larizza D, Dianzani U

Abstract excerpt

Secreted phosphoprotein 1, also known as Osteopontin (Opn), is a proinflammatory cytokine involved in the TH1 response and is highly expressed in the islets and pancreatic lymph nodes of non-obese diabetic mice before the onset of diabetes. In humans, typing of the +1239A/C single nucleotide polymorphism (SNP) in the 3UTR of the Opn gene (SPP1) showed that +1239C carriers displayed higher Opn serum levels than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to HLA-DQ alpha-Chains

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Share to Osteopontin

Share to Protein Multimerization

Source

Identifiers

PMID: 20378012
DOI: 10.1177/039463201002300124

Genes

SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The osteopontin gene +1239A/C single nucleotide polymorphism is associated with type 1 diabetes mellitus in the Italian population.PMID 20378012Read ↗

Association of alleles at polymorphic sites in the Osteopontin encoding gene in young type 1 diabetic patients.Semantic proximity Read ↗

Investigation of osteopontin levels and genomic variation of osteopontin and its receptors in Type 1 diabetes mellitus.Semantic proximity Read ↗

The impact of osteopontin gene variations on multiple sclerosis development and progression.Semantic proximity Read ↗

Decoding SPP1 regulation: Genetic and nongenetic insights into its role in disease progressionSemantic proximity Read ↗

The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease.Semantic proximity Read ↗

Phosphoprotein 1 (osteopontin) gene (rs4754) affects markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus.Semantic proximity Read ↗

Association of an Osteopontin gene promoter polymorphism with susceptibility to diabetic nephropathy in Asian Indians.Semantic proximity Read ↗

DC-SIGN polymorphisms are associated to type 1 diabetes mellitus.Semantic proximity Read ↗

Thirteen single-nucleotide polymorphisms in the human osteopontin gene identified by sequencing of the entire gene in Japanese individuals.Semantic proximity Read ↗

Two single-nucleotide polymorphisms in the 5' and 3' ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

TIM-3 polymorphisms in type 1 diabetes families.Semantic proximity Read ↗

Quantitative genetic study of the circulating osteopontin in community-selected families.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.